PVC/PVC Single-Dose Blister Thermoforming Machines (Pharmaceutical Line)
Automatic thermoforming machines with FFS (Form-Fill-Seal) technology dedicated to the pharmaceutical market represent the state of the art in packaging single-dose liquid and semi-solid solutions.
This category is fully designed to operate with the PVC + PVC configuration (high-rigidity plastic blister), replacing glass ampoules and pre-molded bottles, rigorously complying with GMP (Good Manufacturing Practices) guidelines and GMP standards.
OPERATING PRINCIPLE (STEP-BY-STEP)
UNWINDING AND HEATING OF THE BASE PVC
The rigid pharmaceutical-grade PVC coil is pulled.
It passes through heating plates with digital control (PID).
It reaches the exact glass transition point of the polymer.
PRESSURE AND VACUUM THERMOFORMING
The heated PVC film enters the molding die.
It uses sterile compressed air (filtered via 0.22 micron elements) and vacuum.
The plastic takes on the exact shape of the plastic ampoules, without micro-cracks.
AUTOMATED PHARMACEUTICAL FILLING
Dispensing nozzles constructed entirely of AISI 316L stainless steel.
Anti-drip system with millimeter volumetric precision.
Filling zone designed for integration with Laminar Flow (LAF) systems.
PVC + PVC THERMAL SEALING
The cover film (also in PVC) is applied over the ampoules.
Under high pressure and temperature, perfect molecular fusion occurs between the two films.
100% hermetic seal, free of glues or adhesives, with no risk of contamination.
CODING AND PARTICLE-FREE CUTTING
The blister passes through the date coder (mechanical engraving in low relief or laser).
Automatic insertion of batch and expiration date.
The press performs a clean perimeter cut, without generating plastic microparticles.
CRITICAL APPLICATIONS IN THE PHARMACEUTICAL MARKET
ORAL SOLUTIONS (VIALS)
Vitamin complexes, hepatoprotectors, amino acid solutions and phytotherapeutic products.
OPHTHALMIC AND INHALATION PRODUCTS
Preservative-free eye drops, artificial tears, nebulizer solutions and saline solution.
GYNECOLOGY AND DERMATOLOGY
Creams, gels and ointments applied via applicators or single-dose ampoules.
HIGH-PRECISION VETERINARY APPLICATIONS
Spot-on pipettes for dermal application (flea and tick control) and oral vaccines.
LEADING WORLD MANUFACTURERS (PHARMACEUTICAL SPECIALTY)
UNIFILL (Origin: Italy)
Key Differentiator: Pioneer and leader in high-performance lines (such as the TR-86). Maximum robustness in rigid PVC shaping.
ROMACO - MACOFAR (Origin: Germany)
Key Differentiator: Engineering focused on maximum sterility. High-precision dosing systems for the pharmaceutical industry.
MARCHESINI GROUP - FARCON (Origin: Italy)
Key Differentiator: Reference in integrated lines that perform PVC/PVC blister filling and automatic cartoning.
SARONG (Origin: Italy)
Differentiating Factor: Specialist in high-barrier single-dose packaging and complex formats (suppositories and ampoules).
ASSORTED VALUE FACTORS (CAMARGO STANDARD)
VALIDATION AND DOCUMENTATION
Installation and Operation Qualification (IQ/OQ/PQ) in accordance with ANVISA/FDA standards.
MOTION CONTROL SYSTEM
Modern machines with independent servomotors ensure blister pack repeatability and filling precision.
DOSING SYSTEM HYGIENE
Systems with peristaltic pumps or rotary pistons in ceramic/316L steel that facilitate disassembly and autoclave sterilization.
CAPACITY AND ENGINEERING METRICS
NOMINAL METRIC:
Cycles per Minute x Number of Die Cavities = Parts per Minute.
PRODUCTIVITY EXAMPLE:
30 cycles per minute x 6 cavities = 180 ampoules per minute (10,800 per hour).
TECHNICAL NOTE:
Operation with PVC + rigid PVC requires a slightly longer thermal welding time to ensure perfect fusion, generally operating between 25 and 35 cycles per minute. |
